منابع مشابه
Discoveries in bacterial nucleotide metabolism.
Mydecision to become a biochemist has its roots in youthful indecision. I grew up on a dairy farm in northwestern Illinois surrounded by domestic and wild animal and plant life and came to love the world of biology. This interest was strongly encouraged by my mother, who had been an excellent student of biology in college but was thwarted by the Great Depression and her family’s poverty from pu...
متن کاملAMP deaminase in piglet cardiac myocytes: effect on nucleotide metabolism during ischemia.
The purpose of this study was to examine in situ regulation of AMP deaminase in newborn piglet cardiac myocytes and to determine its role in nucleotide metabolism during ischemia. When a rapid deenergization paradigm was used to assay AMP deaminase, enzyme activity depended on the hormonal and metabolic status of cells just before deenergization. Inosine 5'-monophosphate (IMP) formation was inc...
متن کاملSignalling in cardiac metabolism.
The heart requires large amounts of energy to sustain contractile function, and is the major consumer of energy in the body on a weight basis. Energy reserves are limited in the heart, so energy in the form of adenosine triphosphate (ATP) must be produced continually by the catabolism of different energy carbon substrates. The heart is an ‘omnivore’ and can use a number of different energy subs...
متن کاملANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism
A cardioprotective response that alters ventricular contractility or promotes cardiomyocyte enlargement occurs with increased workload in conditions such as hypertension. When that response is excessive, pathological cardiac remodelling occurs, which can progress to heart failure, a leading cause of death worldwide. Mechanisms underlying this response are not fully understood. Here, we report t...
متن کاملNucleotide Metabolism – Purines and Pyrimidines
Nucleotide metabolism results in the synthesis of the four nucleotides that form DNA. These are further divided in two categories: purines and pyrimidines. Their construction and degradation takes place in a progression of single steps, while different enzymes and cofactors are involved in the process. Beside degradation, there is also a form of reprocessing purine and pyrimidine nucleotides, d...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1953
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.1.1.12